Yep! Same thing happening here. It's intermittent. Not a very professional program with problems like this. I've noticed the Melodyne "D" crash happens more if you change the tempo of the song after melodyning. It's good that melodyne cache file ends up stretching to the new tempo of the song (cause for the life of me I can't get tracks that follow the "internal" chord track to change to new tempos etc - another bug) but it doesn't like it when those melodyne cached files need to be re-cached for the new tempo change so it doubles up and causes a crash. Annoying.
Presonus - Studio One 5 has way too many problems. Transpose often comes undone too and events with Transpose end up reverting to their original pitch even though the transpose says +4!
Have you found a solution for the crashing yet ucifehaul? And to the other person who answered, no, I'm shouldn't have to bounce to avoid Studio One crashing on features it highly advertises and uses to claim professionalism.