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No audio out from Quantum 2

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asked Sep 8, 2020 in Thunderbolt - Quantum by lawrenceminson (140 points)
2012 Mac Mini 2.6 i7 16 gig RAM 1Tb SSD High Sierra, Quantum 2. Recently upgraded to S1 V5 and found Waves V11 plugins coming up blank. Updating to Mojave fixed the issue with the Waves plugins but now I have no audio output from Quantum 2. Input is working and showing level. I've checked the Quantum 2 on my laptop (High Sierra) and it's working fine. I get no output showing on the Quantum 2 and nothing on the input of my DAW. I've tried all 4 inputs. Also tried a different thunderbolt cable. Reinstalled Studio One, updated the Quantum 2 firmware although it was already up to date. Problem is the same on V3 and V4 as well as V5. Tried updating to Catalina but the problem persists. Seems to be a compatibility issue with Quantum 2 and Mojave and Catalina but the Presonus website says that it should be compatible with all Mac OS from late 2011. Any suggestions would be greatly appreciated :)
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