Not an answer sadly, but a note on the same thing. On Mac with OSX 10.11.4 and latest version of S1. Same thing. Indicator lights at the bottom light, but no actual transport. Moving the on-screen playback cursor has no effect, playback never begins. No errors on startup, no failures on close. Rebooting fixes, but consumes a lot of time. Have a faderport (which also reflects the right status on the buttons). Plugging/unplugging the faderport has no effect. No other MIDI devices configured or connected.