Just a quick idea.
Lets say I have 8 analog outputs. That makes 4 stereo pairs.
Assign 1/2 to speakers A
Assign 3/4 to speakers B
Assign 5/6 to speakers C
Assign 7/8 to speakers D
Make sure to switch on the Cue-Mix on all speakers or in my case headphone outputs.
To be able to see the Cue-Mixes in the console you may need to toggle their visibility.
After you have done that you can create a simple Bus and send all your signals to that Bus instead of the master out.
Now you can send the Bus to speakers A and all the other speakers can be feed by cue-mixes from that Bus. Or as in my case, my headphones.
And in the ouput section of the console you can change the outputs and also the low-latency monitoring.
Hope that helps.
All best,
Markus