Intel NUC computers have not been qualified by PreSonus.
These computers are geared for High-End business applications, regardless of specs, generally do not perform for DAW / Real Time Processing environments. Power efficiency being one problem area.
Lack of expansion cards limits FireWire compatibility (and under powered systems also put FireWire out of the question). Some models do have ThunderBolt 3, but again, the eco-system of the computer may still not perform as expected.
Purchase with caution.