I was very excited about trialing Studio One Prime as I have been waiting for a replacement for Cubase (having used it since the 1980s). I can't get my USB keyboard (Line6 KB37) to trigger samples. It is also the USB interface and will playback step time recordings but I can't trigger drum or sample sounds from the keyboard. I have checked that the KB37 is the selected input and output device. It works with my Cubase and other DAW software.
I am using a PC with an i7 processor and 16GB of RAM, Windows 10 and a Line 6 KB37 interface (works fine with my version of Cubase).