Make sure you have the most recent version of the UC, if you are using the a driver installation disk it may be out of date. If you have already done so it could be a handful of things, try a different USB port and only use the ones on the back, if you have another USB cable try that, its the same as a printer cable, does the light on the Audibox even come on when you hook it up? Also in S1 make sure under configure audio device its set to the Audiobox.