Please try going into Studio One>Options>Audio Setup>Processing and set your Dropout Protection to "Maximum." You may also want to try adjusting your Device Block Size. Try setting the Device Block Size lower than 512.
Since you are using a third party devices, and not Presonus devices, open Studio One > Options > Advanced > Services and disable "Presonus Hardware Support," and "Presonus Legacy Hardware Support." Restart Studio One and try again.
PreSonus has been seeing some issues come in with high CPU usage when using the Focusrite interfaces. This issue has been logged internally for tracking. You may want to reach out to Focusrite as well. They may have an update available that resolves the issue or know of a possible workaround.