With the iOne your Radium will need to connect directly to the computer with its built in USB MIDI.
The AudioBox iOne Device Port lets you use an Apple-compatible 30-pin or Lightning-to-USB cable to connect your AudioBox to an iPad when recording and playing back from audio applications. (We recommend using the cable included with the iPad, as results may
vary with non-Apple cables.) See iOS Devices for minimum system requirements.
To set up in a DAW, for the audio engine choose the AudioBox ASIO driver, and for MIDI choose the Radium port.
If you are still having issues, please create a ticket to technical support.