Sorry to hear about the recent issues you have been experiencing.
Here are the general troubleshooting steps for this issue:
1. Please make sure Windows is optimized: https://www.sweetwater.com/sweetcare/articles/pc-optimization-guide-for-windows-10/
2. Set Options > Audio Setup > Processing > Dropout Protection to Maximum. This is a new feature that is very powerful. I recommend reading up on DropOut Protection in the Studio One Reference Manual.
3. If you open the performance monitor in Studio One, you can view the resources that are being used by each of your plug-ins. See if you can find a particular plug-in or set of plug-ins that might be causing the issue.
In case none of that helps, and because going through official support will be needed to dig deeper into the issue, please create a support ticket.
Here is a link to create a ticket: http://support.presonus.com/hc/en-us/requests/new