Yes. Sort of...I have the latest OS X version (10.11.2) on the 3.1 GHz Intel Core i5 (Retinal display) and it downloaded Studio One 3 Artist with all available (i.e., included) add-ons very quickly and without issue. iTunes is also working, though currently limited to only the few purchases I have registered on the iTunes Store, not my entire CD ripped collection as stored on my PC's external 3 GB hard drive. I have successfully recorded audio from an external device that was added (i.e., because it did not exist in the StudioOne instrument options listing) and communicating to the program via USB through the PreSonus AudioBox iTwo interface. (FYI: the Studio One 3 Artist download was included with the AudioBox iTwo purchase. Whether or not I upgrade to the full "Pro" version will depend on what I am able to achieve with the "free" version.)