That 'Release Audio In Background' setting in S1 Audio IO Setup might help you.
I run VB Audio Voicemeeter to manage my windows audio.
That lets me run YT and all desktop audio simultaneously with Studio One
If I want to get fancy I can run Studio One Inserted into Voicemeeter and do crazy stuff like record browser audio or use plugins on my /windows//browser audio.
I'm currently running VM Potato but Banana and Vanilla will do the same tricks, just less channels,