Seems anywhere from 2hrs to sitting overnight that playback becomes inactive. Task Manger looks like S1 is running normal. Notice the message window in Superior Drummer 3 says "Audio Device has become inactive..."
Windows power scheme: Ultimate
Sleep setting: Never
See video: https://photos.app.goo.gl/9wpyWjahEhFRLiyx8
Studio One 4 Pro
Windows 10 Pro
RME Fireface 400 (firewire)
ALL SOFTWARE UP-TO-DATE