Presonus Sphere, StudioOne 5.1, Dec 2020... Exactly the same problem.. Have tried reinstalling, changing locations, rescanning plugins, manually registering Melodyne and site crashes... Lost a days work between trying to get Melodyne to work and CONSTANT random freezes of the computer. Freshly installed windows, antivirus off, FULL legit plugins, 24G ram, 8 core 4.0 Processor with a Universal Audio Apollo 6 firewire and 1050video card for full processor usage on audio and daw...