Outside of 2 channel playback, what you're looking for won't be possible with a consumer media player application.
What you're looking for is a Dolby 5.1 or DTS 6.1 codec that will support playing audio out of multiple pairs using WDM Drivers. These codecs are available from companies like CyberLink can be loaded into a software based DVD Player that can decode the encoded surround signal from an MKV file or DVD disc in the drive.
PreSonus does not support, nor has tested or qualified any of these codec's with these players with any of our multi-channel audio interfaces for home theater surround playback. Universal Control does not have any way of managing LFE channels.
Be sure to contact the Media Software playback companies about device compatibility before buying.