Make sure you've installed the latest Universal Control from the product download page so you have the latest drivers installed.
The audio interface in the bundle has it's own download page, select it here: https://www.presonus.com/support/downloads
Windows will want to reinstall the driver for every USB Port you plug into.
Try plugging it back into the same USB port you had when it was connected the first time.
Then, with some patience, unplug and plug into each USB port on your system and let Windows initialize it for each new USB port you're plugging in. Let the system install the drivers for each new port. When you've done all your ports, then you won't have to remember which port to plug it into again later.
This is not an issue for Mac OS X, this is unique to Windows systems, it's always been this way for devices that have custom device drivers.
