It may be by just coincidence that your speaker started making noise at the same time you installed Studio One Prime. You need to troubleshoot all of your audio cables to make sure they're all properly connected.
You can use our Tech Support article about noise issues to determine if the issue is in your system, speakers, cables, or external interference.
The issue may be your speakers, try plugging them into a different outlet.
If you're issue persists, open a support request in your https://my.presonus.com account so a support team member and further assist you.