I'm still having trouble getting mine to connect. Here is the trouble ticket I just sent to Presonus support:
My iMac with Catalina 10.15.7 isn't connecting with my Firepod interface. I have used them together before, but they don't work now. I have downloaded the Catalina-compatible Universal Control and Firewire Driver, both v.3.6.0 and 3.6.4.. I used the uninstaller, restarted, and reinstalled the new drivers. Still doesn't connect. The Firepod does not show up on the "Sound" tab in System Preferences. I have tried different cables, adapters and plugs.