Thanks for your efficient reply, Saga!
Please understand, I had not advanced to setting up Studio One Professional 3.2 for Song creation just yet -- I only went through the complete download, full software installation and initial "Audio Preferences Setup" phase.
If I understand your Reply correctly, then -- I shouldn't worry that Studio One won't permit me to globally set the sample rate to 48kHz in Audio Preferences. I should be happy doing it a bit later, when I'm ready to enter Song Mode. Am I correct?
While I certainly don't understand PreSonus' reasoning behind that restrictive arrangement (as I suspect it should cause angst and consternation for newcomers having the same quirky "audio interface being forced back down to 44.1kHz, via S1 v3 preferences -- I'm willing to accept this coercive software behavior if I must. Honestly, I believe PreSonus ought to advise endusers within the Preferences panel that this setting there can be overridden when they begin a new song in Song Mode.