For those who this might help. I just got hipped to this software on Reddit. It's apparently reputable and safe, but you can decide for yourself:
https://rogueamoeba.com/soundsource/
Under settings/preferences/audio, there's a setting to turn on Super Volume Keys, and boom! keyboard volume controls work again. Plus there's quite a few cool things about the SoundSource app.
I was happy to find this. Pretty annoyed when I got an iTwo interface only to find it didn't support the keyboard volume keys. My PreSonus Firepod has allowed me to use them for the last 15 years or so. Anyway, problem solved though I'd rather not have to run this extra software just to get this expected functionality...
Cheers.