Some computers feature USB ports which always provide power even after system has shut down. These ports are sometimes colored yellow, or are labeled a special way. These ports may prove problematic for use with the AudioBox USB.
Luckily there is a setting in your BIOS which is designed to save your system power when it's not in use called EuP or ErP.
By enabling EuP Ready or ErP Ready option in the Power Settings section of your system BIOS will properly shut down power to all USB ports when the system is shut down. This will ensure that the AudioBox will be seen by the OS correctly upon reboot.
Note: PreSonus does not support sleep mode for any AudioBox USB or AudioBox VSL Series products. Be sure to shut your system down fully when not in use.