I had my CPU SPIKING making all sorts of popping and crackling , looked at youtube for hrs. with no help, all people were talking about was the audio device settings. That didn't help. My friend told me about the UNIVERSAL CONTROL ( Hardware ) window , this section was not in the studio one main page, it was in the SHOW HIDDEN ICON section on the main computer screen. There I found the SAMPLE RATE, CLOCK SOURCE, BLOCK SIZE, INPUT FORMAT, OUTPUT FORMAT. Once I changed the BLOCK SIZE the CPU went back to normal !!!!!
I know I just read about the buffer size, but a little plain talk there would help. Please show this answer, I am sure someone needs to know this. Thanks Presonus. Randall Roop