The issue I have encountered is similar to the original poster's issue. In addition, I have interference when I move my mouse in any application as well as with the DAW I'm working in. With any click or movement of the mouse, the interference sound was amplified through the Audiobox headphone output.
A powered USB 2.0 hub solved it for me. Apparently it wasn't getting enough power, which makes sense. That has been the issue with other USB powered devices I've had problems with in the past (external hard drives, etc.) I tried two different models. One of them didn't solve the issue, but one did (this is not a plug for Macally, only my own findings). I've read elsewhere that the ports must be 2.0 compatible, which is why I opted for 2.0 models.
This model solved the issue- Macally 4-port powered USB 2.0 hub with 5V/2A power supply.
This model did not solve the issue- Amazon Basics 7-port USB 2.0 with 5v/2a power supply.
I hope this helps some people.