ROBERTGRAY3 - The drive that contains the installation of Studio One is the C:\. It's a 2TB SATA 6Gb/s 7200RPM drive that has 1.81TB free. It is formatted as NTFS.
To add to the mystery, I am noticing that the issue does not exist across all songs, only a few of them. What is really frustrating, though, is that I cannot find anything obvious that the songs have in common, except for the use of SampleOne. But, SampleOne is also used in the songs that do not have the issue. Other than that, there is nothing in the way of clues in the system's performance monitor, my CPU is keeping a nice, cool 33-degrees C (so I can rule out overheating), RAM seems to be in check (spiking at 20% use, but normally a lot lower than that). I have run error checking diagnostics on the hard drive, but have come up empty. No viruses, no malware. It's a head-scratcher, for sure.