From what Presonus has added to their website regarding version 4's new functionality, it doesn't appear MPE is supported. It's possible I missed it. I have version 3.5 and was hoping to see MPE supported in this next release. Might have to wait until Version 4.5 or beyond. Currently, from the feedback I've received thus far, it appears Presonus won't share if they're investing in MPE. If I hear anything new, I'll post it here, please do the same. You're not alone, there are a number of folks who are looking for MPE functionality. Thanks!