Ok so I had this issue and I solved it using Steinberg's Cubase forum!
The issue was a mistmatch between my Presonus Studio 24c Sample Rate and Window's Default Format. For example, if you DAW project is set to 44k and your Presonus to 41, the audio interface will "take over" and prevent windows from using the bus. To fix this you need to change window's default sample rate to the one u usually set your DAW project with work with.
Go go Control Panel -> Hardware and Sound -> Sound -> Right click your Presonus' Main out device (Default device) -> Properties -> Advanced -> change the Default Format to the one your DAW uses. That's it!
Hope it helped, Shay.