Please check out these two guides, which will assist you in setting up your AudioBox:
http://support.presonus.com/entries/21351334-why-won-t-my-audiobox-record-or-play-back-audio
Windows Vista and Windows 7: http://support.presonus.com/entries/21524610-how-do-i-uninstall-and-reinstall-my-audiobox-drivers-in-windows-7
Windows 8, 8.1 and Windows 10: http://support.presonus.com/entries/21469744-How-do-I-uninstall-and-reinstall-my-AudioBox-drivers-in-Windows-8-or-Windows-10-
If the issue remains, please create a ticket to technical support.
Here is a link to create a ticket: http://support.presonus.com/hc/en-us/requests/new