Currently dealing with the same issues on a custom rig(specs below.) I've uninstalled/reinstalled following all presonus guides. Restored the P.C. twice. Still not getting any audio from my monitors. I think the driver isn't routing sound correctly/basically not windows 10 compatible, but I'm not so sure. I have sound from my monitors when I turn on 48v and have mic hooked up, just no audio from computer. Probably related to the outdated drivers. Their engineers have known of the issue for years, but they are developing for the new equipment. . .I'll probably get something newer and not presonus.
Windows 10, i3 8100, gigabyte b360s d53h mobo f11 bios, 8gb corsair ram, Audiobox USB