I've seen several questions/articles/etc. that describe similar problems to what I'm having, but so far haven't found anything that's worked for me. I have a Studio 2|4 usb interface and a Windows 10 Desktop computer, and I'm getting constant "noise" (like a crackling/hissing) from the monitors that are connected to the interface's output. It doesn't matter what I have the instrument levels set at, or what the mixer or output levels are, or even whether I have an instrument connected or whether the Studio One application is running. If my computer is on, and the monitors are turned on and connected to the interface, I get the noise.
I used these same monitors with my previous interface and didn't have this issue, so I'm pretty sure it's not a problem with the monitors. I've already tried some of the solutions found on this site-- using a powered USB hub, re-installing drivers, and making sure I'm plugged into a USB 2.0 port, for example. Any idea what else could be causing something like this?