Here's an example of why this would be useful.
On Windows you can set the loop end/start with the following commands
Ctrl + Mouse click = Loop Start
Alt + Mouse Click = Loop End
Alt is to the right of ctrl, which is logical. Ctrl sets the start and Alt sets the end
This is inverted on Mac where alt is to the left of cmd so while it is consistent with key names, from a visual/spacial perspective it is back to front.
The issue becomes really apparent when you regularly move between the Mac and Windows and you have to fight your muscle memory.
It may seem like a small problem but cumulatively I've probably lost days of my life mis-clicking.