Hey, Joel and future people that might have the same problem.
I just had a problem similar to this one this morning, although I'm not sure it has the same causes.
I was editing a podcast, using one macro that I created a while ago to speed up my workflow, and, for the new session that I started for a new episode, I just clicked "save as" from the previous episode (beacause it is faster for this specific project. I know there are templates et al, and I use them too).
The thing is, for this new episode, I could cut and drag with my mouse just fine, but whenever I used my macro (which does the same thing, only condensing 4 mouse clicks/keytrokes into one), it took like 5 seconds for the DAW to respond and resume playback.
Obviously it ****** me off, because now I was going to lose more time working than if I didn't use the macro at all. So I tried rebooting the computer, I tried cleaning the cache folder, I tried saving the previous episode as a new project...
Anyway, nothing having worked out, I just resigned myself to working without the macro...
BUT, by pure chance while working, I accidently hit the "a" on the keyboard, and, to my surprise, I noticed that all the automation I had written in the previous episode (EQ bypass, volume, and even a reverb send that didn't even existed in this episode) was still present and was written and cut and all to suit the events everytime I used my macro.
So I erased all the automation and, lo and behold, everything was running perfectly once again when I used the macro.
Sorry for the long reply, so I'm writing a short advice now:
Check if you have automation written on that track.
I hope this can help future persons with the same problem that I had.