I would think you could route a channel or channels that you want to use that plugin on into you studio one recording daw via usb, avb, etc into a track or tracks then assign that plugin on it, then re-route that back onto the rack mixer. Essentially using the daw in a channel insert type of situation. I can do it om my RML32ai via firewire into daw. Wouldnt see why you couldnt do it with the series 3 mixers.