Here as a example of my Akai MPD 232 in S1 4.1
My Akai MPD232 is connected to a powerd USB Hub. But you can also send and receive time synchronisation over MIDI IN/OUT if you need this setup. You can control your Akai MPD from Studio One with the Send To option (time sync). In this case set the Akai MPD to "External Mode" (Akai Seeting mode "Global Option: Clock Source External")
The drum layout is compatible with Impact XT, so Bank A - B0 starts in the lower left corner. But you can change this with Akai MPD Editor presets.
Hope this helps