Question

I'd like to connect the outputs of the AudioBox iTwo to two mono channels on my mixer that has unbalanced 1/4" phono inputs.

Answer 1

Use a 1/4" X 1/4" line level (not SPEAKER) cable (instrument cables work fine here) You could use 1/4" ballaced (TRS) cable but no benefit will likely be realized doing this, I even use standard RCA/RCA and RCA/1/4" adapters.

A good quality cable will be less likely to suffer interference, but esoteric cables are not necessary.

Answer 2

Changing from TS to TRS cable from the output of my 1818VSL to my Mackie mixer just eliminated a pesky ground hum that i had been trying to resolve for sometime. So my response is that TRS cables CAN be a benefit if the receiving hardware is able to connect as a TRS balanced line.