I just wanted to say that I was (or am) struggling with the exact same issue - after some thorough research tonight I can offer you a couple of solutions, one of which solved my problem at least for now. None of this is guaranteed to work however, and I hope that someone with more insight will reply here soon.
1. Check your energy settings. I had bullsh*t like PCI hybernation mode etc. activated, even though I had chosen the PreSonus Energy profile!! This effectively meant that my usb pci hub to which my Virus TI is connected sometimes just stopped responding, often crashing the entire song in the process. I could imagine that this kind of hard crash you're experiencing can be caused by this as well.
2. "Studio One will sometimes hang or freeze when Hardware Integration is loading up.
Below is a manual fix to this issue:
Go to Start >> Computer >> Type in %appdata% in the browser >> PreSonus >> Studio One
Locate the "Services.settings" file >>
Open it with Notepad >>
For the heading that says "<Attributes friendlyName="PreSonus Hardware Support" enabled="1"/>"
change the '1' to a '0'
so it should look like that exactly, with a 0.
Go to File >> Save. >> Then, close the file.
Restart Studio One and the problem should be fixed."
3. I read somewhere that a recent Apple Quicktime / Bonjour update made Studio One crash on startup, or quite randomly. Maybe disable Quicktime support in the advanced settings and see if that helps?
Should you have any further leads on this issue, please let me know!! It was happening to me at least 20 times last week and it made me insane.