I have an Asus PRIME Z690-P WIFI D4 with the ThunderboltEX 4 card installed and the Quantum 2626 is only synced if the interface is powered on before starting the computer. If the computer is on and then the interface is turned on the device is recognized in the Thunderbolt Control Center, but not synced. Tested on a Gigabyte computer with their TB3 expansion card and it hot plugged no problem several times.