Yeah it's some type of sync issue I think that Presonus needs to look at., I turn on my win 10 desktop, let it start up all the processes, after a few minutes I'll turn on the conditioner that the Quantum is plugged into, without turning the Quantum on. I leave that sit for a few minutes to make sure the thunderbolt gets started, then I kick on the Quantum and it usually syncs. However it seems that when I turn off the Quantum again, and then back on it won't resync, so I reboot. Seems to work most of the time, hope that helps anyone having problems.
Aaron