Question

Can you receive audio over USB like an external sound card?

Answer 1

Certainly.

The iOne is exactly that, a soundcard.

If you're trying to use the device for general playback on your computer please see the link below:

http://support.presonus.com/entries/21486905-How-do-I-set-my-AudioBox-as-my-computer-s-default-output-

 

*NOTE: If you're using PC you'll want to make sure you install the drivers found here

http://www.presonus.com/products/AudioBox-iOne/downloads