Thank you for contacting Presonus Technical Support. Sorry to hear about the recent issues you have been experiencing.
Please delete your Studio One preferences and test again.
Quit Studio One
From the Finder toolbar, click Go, hold Option, and click Library
Open Application Support/PreSonus Software/Studio One 3
Copy the contents of the folder to a folder on your desktop for use as a backup.
Delete all files and folders except for the user.license file
Launch Studio One 3 and test for this issue again. If the problem still exists, please feel free to copy your settings files back over from the backup you created in step 4.
*If you are missing any Sound Sets after doing this, simply go to Documents>Studio One>Sound Sets and double-click one of the files.
If the issue remains, please create a ticket to technical support.
Here is a link to create a ticket: http://support.presonus.com/hc/en-us/requests/new