Thank you for contacting Presonus Technical Support. Sorry to hear about the recent issues you have been experiencing.
Please delete your Studio One preferences and test again.
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Quit Studio One
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From the Finder toolbar, click Go, hold Option, and click Library
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Open Application Support/PreSonus Software/Studio One 3
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Copy the contents of the folder to a folder on your desktop for use as a backup.
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Delete all files and folders except for the user.license file
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Launch Studio One 3 and test for this issue again. If the problem still exists, please feel free to copy your settings files back over from the backup you created in step 4.
*If you are missing any Sound Sets after doing this, simply go to Documents>Studio One>Sound Sets and double-click one of the files.
If the issue remains, please create a ticket to technical support.
Here is a link to create a ticket: http://support.presonus.com/hc/en-us/requests/new